ABSTRACT
Immunosenescence and inflammaging are two fundamental age-related changes substantially paving the way to accelerated aging, multidimensional frailty, and poor outcomes of several illnesses including COVID-19. A common misbelief is that immunosenescence and inflammaging, like other age-related changes, are exclusively detrimental. However, they are inserted in a highly complex landscape of physiological changes occurring with increasing age at the biomolecular, organismal, psychosocial, and functional level. The understanding of this complex picture is fundamental to develop strategies aimed at maintaining robustness. Groundbreaking descriptions of frailty paved the way to successful interventions to maintain and restore robustness. To date, frailty is well established as the very core of geriatric medicine, going far beyond multimorbidity and chronological age. © 2023 Elsevier Inc. All rights reserved.
ABSTRACT
The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere dysfunction, cellular senescence, and epigenetic changes. The FRAILOMICS initiative is exploring many of these through various omics studies. Translating this knowledge into new therapies is being addressed by the U.S. National Institute on Aging Translational Gerontology Branch. Research gaps identified by the Task Force include the need for improved cellular and animal models as well as more reliable and sensitive measures.
Subject(s)
Aging , COVID-19 , Animals , Biomarkers , Humans , Pandemics , SARS-CoV-2ABSTRACT
The authors apologize for a typing error that occurred in the September 2020 article that changes the meaning of a sentence. Correction: Page 921, right column, 2nd paragraph, line 8, change «match» to «watch» so it reads, «Primary care providers should watch for frailty development due to physical inactivity during the COVID-19 pandemic (47).» In addition, the author listed as “C. Won Won” wishes to be known as “C.W. Won.” © 2020, The Journal of Nutrition, Health & Aging.